Health Condition 1: M511- Thoracic, thoracolumbar and lumbosacral intervertebral disc disorders with radiculopathy
Conditions
Interventions
Intervention1: Intraoperative use of dexmedetomidine: Patients in group D are given 1µg/kg Dexmedetomidine over 15 min followed by 0.5µg/kg/hour
Control Intervention1: Intraoperative use of lignocaine
Sponsors
St Johns Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: All ASA I and II adult patients aged 18 years to 80 years posted for lumbar spine surgeries
Exclusion criteria
Exclusion criteria: 1.Pregnant and lactating women 2.Patients with intellectual disability ,dementia and alzheimer’s disease 3.Known history of hypersensitivity to local anesthetic agents 4.Coagulopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess duration of analgesia between the two groups (Lignocaine vs Dexmedetomidine) in the postoperative periodTimepoint: Duration of analgesia:Time from stop of study drug to first request of analgesia | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the hemodynamic parameters such as heart rate, Systolic blood pressure(SBP), Diastolic blood pressure(DBP) and Mean arterial pressure (MAP) and Saturation (SpO2) intraoperatively between the two groupsTimepoint: Hemodynamic parameters -HR, Blood pressure (SBP, DBP and MAP), SpO2 is monitored every 15 min until end of surgery.;To assess the total rescue analgesic (Ketamine) consumed between the two groupsTimepoint: Total rescue analgesic ( IV Ketamine) consumed at the end of surgery;To assess total analgesic consumption of lignocaine and dexmedetomidine.Timepoint: Total analgesic consumption of the study drugs.(lignocaine and dexmedetomidine);To compare side effects between the two drugs.Timepoint: Side effects like PONV, sedation, respiratory depression (Respiratory rate8) and Desaturation (SpO294%) on arrival to PACU, 20min, discharge from PACU, 2hrs,4hrs, 8hrs,12hrs and 24 hrs;To assess the total dose of rescue analgesia used postoperatively between the two groupsTimepoint: Total dose of IV PCA Fentanyl used at the end of 24 hrs;To assess NRS score at rest & movementTimepoint: PACU at 20 min, discharge from PACU 2hrs,4hrs,8hrs,12hrs & 24hrs | — |
Countries
India
Contacts
Public ContactDr M Manjuladevi
St Johns Medical College and Hospital
Outcome results
None listed