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Which Volatile Anesthetic agent causes more increase in blood flow to brain during Brain Tumor Surgery

Comparison of cerebral vasodilatory effects of sevoflurane, isoflurane & desflurane in patients undergoing surgery for supratentorial lesions under general anesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/053987
Enrollment
90
Registered
2023-06-16
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D330- Benign neoplasm of brain, supratentorial Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Transcranial Doppler: Transcranial Doppler will be used to measure Change in Blood flow Velocity in Middle Cerebral Artery and Pulsatility Index during Induction of Anesthesia till MAC

Sponsors

National Institute of Mental Health and Neurosciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Unilateral Supratentorial Lesion ASA Physical Grade 1 and 2

Exclusion criteria

Exclusion criteria: Refusal of Consent Patients with Poor Acoustic Window Hemodynamically unstable patient requiring inotropic infusion Plaques/Stenosis observed on Carotid Artery Doppler in the preoperative period the day before surgery

Design outcomes

Primary

MeasureTime frame
To compare Change in Mean Blood Flow Velocity in Middle Cerebral Artery among the 3 Volatile anestheticsTimepoint: Baseline to 1 MAC—

Secondary

MeasureTime frame
To compare Pulsatility Index among the 3 Volatile AnestheticsTimepoint: 1 MAC;To compare Regional Oxygen Saturation (rS02) among the 3 Volatile AnestheticsTimepoint: 1 MAC;To compare the effects of 1 MAC of Isoflurane Sevoflurane & Desflurane on Middle Cerebral Artery Flow Velocities between the cerebral hemisphere with tumor and normal sideTimepoint: 1 MAC—

Countries

India

Contacts

Public ContactDr Sudhir Venkataramaiah

National Institute of Mental Health and Neurosciences

vsudhir77@gmail.com9900793108

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026