Health Condition 1: C719- Malignant neoplasm of brain, unspecified
Conditions
Interventions
Intervention1: Ringers Lactate Infusion: RL will be used as intraoperative maintenance fluid
Control Intervention1: Normal Saline Group: NS will be given as intraoperative fluid
Sponsors
PGIMER CHANDIGARH
Eligibility
Inclusion criteria
Inclusion criteria: 1) Adult patients scheduled for elective craniotomy for supratentorial tumors under general anaesthesia with tumor volume routinely. 2) Patients above the age of 18 years and below 65 years. 3) ASA I to ASA III patients.
Exclusion criteria
Exclusion criteria: 1) Patients with deep seated and skull base tumors. 2) Patients with tumor volume >200ml. 3) Patients with CKD or those undergoing renal replacement therapy. 4) Patients with Chronic liver disease. 5) Patients receiving diuretic therapy preoperatively. 6) Pre-existing dyselectrolytemia. 7) Massive intraoperative blood loss. 8) If the patient requires hyperventilation to paCO2 <30 mm Hg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare measured values of serum osmolality in neurosurgical patients receiving Normal Saline vs Ringers Lactate during elective craniotomy for Supratentorial tumors at the end of the surgery.Timepoint: After Induction And At the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain Relaxation ScoreTimepoint: at dura opening and at closure;Changes in hemodynamic parametersTimepoint: every 15 min from induction.;Comparison of the following parameters from baseline amongst the groups â?¢ Rise in osmolality from baseline in each group â?¢ Serum electrolytes â?¢ pH â?¢ LactateTimepoint: After Induction And At the end of surgery;MRS at dischargeTimepoint: at discharge;Total Blood loss, Blood and blood products infusion.Timepoint: At the end of Surgery;Total urine outputTimepoint: At the end of Surgery;Total volume of fluid (crystalloids and colloids) used.Timepoint: At the end of Surgery | — |
Countries
India
Contacts
Public ContactDr Ankita Chauhan
PGIMER, Chandigarh
Outcome results
None listed