Health Condition 1: E660- Obesity due to excess calories
Conditions
Interventions
Intervention1: Yoga-based lifestyle intervention: Yoga-based lifestyle intervention (YBLI)will have pre-tested YBLI for 6 months along with dietary guidelines.This intervention program will be an outp
Sponsors
Department of Science and Technology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Body Mass Index (BMI) > 25 kg/m2 & 2. Participants must be able to participate and comply with the intervention, and preferably from the National Capital Region (NCR). 3. Participants should be able to read & comprehend the administered questionnaires 4. Patients having mild or moderate depression as per Patient Health Questionnaire (PHQ-9) and Beck depression inventory (BDI-II) 5. For Major Depressive Disorder (MDD), the patients must be fulfilling criteria as per DSM-5, (MDD to be diagnosed by a Psychiatrist).
Exclusion criteria
Exclusion criteria: 1. Patients with morbid obesity, BMI > 35 kg/m2 2. Patients having uncontrolled diabetes mellitus 3. Patients having uncontrolled hypertension 4. Patients with a disease of the thyroid gland and other chronic illnesses/autoimmune diseases/psychiatric disease. 5. Patients with severe physical ailments like myocardial infarction, fracture 6. Patients with severe depression (BDI-II scale score >=45) 7. Patients with suicidal tendency 8. Participant involved in any kind of exercise or physical activity and yoga-meditation therapy in last 6 months prior to enrolment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the effects of a 6-month yoga-based lifestyle intervention in patients with obesity & comorbid depression (including MDD) with respect to changes in: 1. stress, inflammation and neuroplasticity in gene expression & blood biomarkers 2. cellular ageing (telomere/telomerase) 3. ultrastructural changes in select cell organelles 4. pain profile (Quantitative sensory testing) 5. BMI, depression level, and quality of life Timepoint: There will be four time points: at baseline, after 1 month, after 3 months and after 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the effects of a 6-month yoga based lifestyle intervention in patients with obesity & comorbid depression (including MDD) with respect to changes in cytokines of stress, inflammation and/or neuroplasticity Timepoint: There will be four time points: at baseline, after 1 month, after 3 months and after 6 months. | — |
Countries
India
Contacts
Public ContactMs. Simran Lalwani
All India Institute of Medical Sciences
Outcome results
None listed