Effect of sequential and continuous irrigation protocols on the healing of tooth with periapical pathology using clinical and radiographic evaluation.

A comparative evaluation of clinical and radiographic periapical healing after continuous and sequential chelation irrigation protocols in teeth with periapical pathology – A Randomized Clinical Study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/053912

Enrollment

Registered

2023-06-15

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS- Health Condition 2: K045- Chronic apical periodontitis Health Condition 3: K045- Chronic apical periodontitis

Interventions

Intervention1: continuous chelation irrigation protocol: Continuous chelation irrigation protocol (2.5% NaOCl containing the freshly dissolved HEDP powder) NAOCL & ETIDRONATE IRRIGATION PREPRATION: Et

Eligibility

Inclusion criteria

Inclusion criteria: 1.Healthy patients (Category: American Society of Anaesthesiologists class 1) (ASA House of Delegates 2014) aged between 18 – 60 years of age will be included. 2.Maxillary or mandibular teeth diagnosed with periapical pathology not more than 3mm (Periapical Index less than 4 given by Orstavik et al20) in dimension will be included. 3.Only those patients ready to sign the consent form will be included in the study.

Exclusion criteria

Exclusion criteria: 1.Teeth with open apex, root resorption and calcified pulp chamber and canals will be excluded from the study. 2.Teeth with curvature more than 20 degree will be excluded from the study 3.Teeth which had received previous endodontic treatment will be excluded from the study. 4.Cases showing periodontal pockets deeper than 4mm will be excluded from the study. 5.Teeth with Flare ups during root canal treatment will be excluded from the study. 6.Any other iatrogenically affected root canal treatments will be excluded from the study. 7.Medically compromised patients will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
The result of the study will help us to determine the efficacy of sequential & continuous chelation irrigation protocols in a tooth with periapical pathology. Moreover, it will help practitioner to get better idea of both irrigation regimes.Timepoint: The result of the study will help us to determine the efficacy of sequential & continuous chelation irrigation protocols in a tooth with periapical pathology. Moreover, it will help practitioner to get better idea of both irrigation regimes. This will be assessed at baseline, 3 months and 6 months.	—

Measure

Time frame

The result of the study will help us to determine the efficacy of sequential & continuous chelation irrigation protocols in a tooth with periapical pathology. Moreover, it will help practitioner to get better idea of both irrigation regimes.Timepoint: The result of the study will help us to determine the efficacy of sequential & continuous chelation irrigation protocols in a tooth with periapical pathology. Moreover, it will help practitioner to get better idea of both irrigation regimes. This will be assessed at baseline, 3 months and 6 months.

—

Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public ContactDr Renu Batra

KM Shah Dental College and Hospital Sumandeep Vidyapeeth

drrenubatra@gmail.com9537528008

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026