Health Condition 1: G300- Alzheimers disease with early onset
Conditions
Interventions
Intervention1: Cognitive retraining: The sample size of the study will be 90. Here we shall follow 1: 2 recruitment ratio- 30 patients
in CR arm and 60 patients in Control arm with age 55 years. The
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients satisfying the DSM-IV-TR along with Peterson criteria for MCI or NIAA criteria for early AD as assessed by the clinician 2) Patients with satisfying performance in the psychological tests (MMSE, RAVLT and other tests), administered and evaluated by psychologist. 3) Educated at least up to grade 10th grade 4) Age group of 55-85 years 5) Malayalam speaking
Exclusion criteria
Exclusion criteria: Patients with metallic implants/pacemakers, neurosurgical history, neuropsychiatric symptoms, claustrophobia, substance abuse, medical conditions that contraindicate performance of MRI Clinical dementia rating scale > 2.5
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MCI conversion to dementia Progression of clinical dementia rating scale (CDR) & IADL scores in early dementiaTimepoint: Sessions weekly for 8 weeks followed by followup neuropsychology assessment at 3 months 1 year followup MRI at 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| MRI changesTimepoint: 1 year | — |
Countries
India
Contacts
Public ContactRamshekhar N Menon
SCTIMST
Outcome results
None listed