Suppression of heart rate, blood pressure & narcotic requirement using multiple non narcotic medications in Laproscopic surgeries under general anaesthesia.

Opioid sparing & suppression of hemodynamic response by preoperative multimodal non-opioid analgesic regime in Laparoscopic Surgeries Under General Anesthesia: A prospective randomized comparative study - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/053847

Enrollment

Registered

2023-06-14

Start date

Unknown

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K353- Acute appendicitis with localizedperitonitis Health Condition 2: K800- Calculus of gallbladder with acutecholecystitis Health Condition 3: O- Medical and Surgical Health Condition 4: K460- Unspecified abdominal hernia withobstruction, without gangrene

Interventions

Intervention1: Opioid free anaesthesia: Group OF will receive Tablet pregabalin 150mg 1 hour prior induction. Intravenous Ketorolac 30mg, magnesium sulphate 30 mg/kg, lidocaine 1.5mg/kg, Dexamethasone

Eligibility

Inclusion criteria

Inclusion criteria: Patients with normal BMI aged 18-65years of either gender with American Society of Anaesthesiologists (ASA) I and II status undergoing elective laparoscopic surgeries under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1 Patients refusing to participate in the study 2 Obese individuals 3 Difficult airway 4 Uncontrolled hypertension, diabetes 5 Cardio-respiratory disorder 6 Allergy to study drug 7 Neuroâ??psychiatric disorders 8 Pregnant or lactating mothers. 9 Hepatic and renal dysfunction 10 Alcoholic 11 Patient on opioids, sedatives, beta-blockers 12 Infection at site of block 13 ASA 3 and 4

Design outcomes

Primary

Measure	Time frame
To compare the suppression of hemodynamic response to intubation & pneumoperitoneum by using multi modal non opioid analgesic regimen in adult patients undergoing elective laparoscopic surgery in comparison with opioid based approachTimepoint: Baseline, After administration of study drug, 2minutes post induction, 5minutes post intubation, Every 15minutes post pneumoperitoneum after extubation	—

Secondary

Measure	Time frame
To assess Postoperative pain relief, opioid consumption for 24 hours, To study the safety profile of the drugs Timepoint: Intraoperative through out the surgery to estimate requirement of opioids, Postoperatively every 15mins for 1 hour, every 2nd hourly till 8th hour, 16th hour, 24th hour.	—

Countries

India

Contacts

Public ContactShankar K

Rajarajeshwari medical college and hospital

shankarkraj111@gmail.com8971719523

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026