Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features
Conditions
Interventions
Intervention1: Active Transcranial Direct Current Stimulation: The participants in the active group will receive stimulation current at 2mA for 20 min with ramp up of 30 sec and ramp down of 30 sec in
Sponsors
All India Institute of Medical Science New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age 18 to 55 years 2.Any gender 3.Right-handed subjects 4.Willing to give written informed consent 5.Ability to read Hindi or English language 6.Meeting DSM 5 criteria for Major Depressive Disorder (MDD) 7.Treatment naive or Treatment free from prior 2 weeks or on a stable standard antidepressant regimen with no change in treatment 4-weeks prior to tDCS intervention 8.HAMD score >= 17 (moderate to severe depression)
Exclusion criteria
Exclusion criteria: 1. Suffering from any other psychiatric disorder or substance use disorder (except caffeine & nicotine) assessed through clinical interview using DSM 5 2. Persistent Depressive Disorder (dysthymia), Premenstrual Dysphoric Disorder, Depressive Disorder Due to Another Medical Condition, Substance/ Medication Induced Depressive Disorder, Other and Unspecified Depressive Disorders based on DSM 5 3. History of seizures 4. Pregnancy/ Lactation 5. Uncontrolled medical illness 6. History suggestive of space occupying brain lesion or cerebrovascular accident 7. Patient having implanted device or metal in brain/head or cardiac pacemaker 8. Allergic to radioligands 9. History of receiving any neuromodulation therapy (e.g., ECT, rTMS, tDCS) within the last 3-months 10. Actively suicidal as defined by a score of 4 on item 3 of HAMD 11. Currently receiving any form of Cognitive Behavioral Therapy or any other Psychotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Score of Hamilton Depression Rating Scale (HAMD)Timepoint: before the first session starts, and then after 1, 2, and 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in Hamilton Rating Scale for Anxiety (HAMA), Trail Making Test and TDCS side effects check listTimepoint: before the first session starts, and then after 1, 2 and 4 weeks;Correlation of Baseline Cortical Activation on SPECT, BDNF gene polymorphisms, and Dexamethasone Suppression Test (DST) to change in clinical symptoms after 2 weeks assessed over HAMDTimepoint: before the first session starts;Serum BDNF levels, changes in activation and connectivity seen in fNIRS and qEEG during resting and activation state,Timepoint: before the first session starts, and then after last session (after 2 weeks) | — |
Countries
India
Contacts
Public ContactDr Rohit Verma
All India Institute of Medical Sciences Delhi
Outcome results
None listed