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Comparison of the effect of two drug patches diclofenac & ketoprofen on pain relief after laparoscopic cholecystectomy operation

A comparative evaluation of transdermal diclofenac patch versus transdermal ketoprofen patch for post-operative analgesia in laparoscopic cholecystectomy.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/053830
Enrollment
114
Registered
2023-06-13
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K801- Calculus of gallbladder with othercholecystitis Health Condition 3: K802- Calculus of gallbladder without cholecystitis Health Condition 4: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: Transdermal Ketoprofen patch: Comparison of the efficacy and safety of transdermal ketoprofen patch(30 mg)and transdermal diclofenac patch(100mg)studied 2hr, 4hr, 6hr and 12hr post-oper

Sponsors

Department of Anaesthesiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients aged 18 to 60 years. 2)Posted for laparoscopic cholecystectomy under general anaesthesia 3)Belonging to ASA physical status 1 and 2. 4)Weight between 40 to 80 kgs. 5)Duration of surgery approximately 60-90 minutes.

Exclusion criteria

Exclusion criteria: 1)Patient with significant cardiovascular,renal, hepatic,neurological disease. 2)Known allergy to study drugs. 3)Chronic use of opioids /anti-inflammatory drugs 4)Patients in whom laparoscopic surgery was converted to open procedure

Design outcomes

Primary

MeasureTime frame
To compare the time to administration of first dose of rescue analgesia in patient receiving ketoprofen and diclofenac skin patchesTimepoint: Post operative period—

Secondary

MeasureTime frame
1)Total duration of rescue analgesic in the first 12 hours of the surgery. 2)Incidence of systemic side effects like nausea,vomiting, gastritis, sedation, dizziness etc. 3)Incidence of local dermal side effects like pruritus, erythema, dermatitis ,etc. Timepoint: Post operative period—

Countries

India

Contacts

Public ContactDR CHIRANJIB BHATTACHARYYA

Institute of Post Graduate Medical Education and Research, Kolkata

bhattach1@yahoo.com9433508030

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026