Health Condition 1: Z992- Dependence on renal dialysis Health Condition 2: N186- End stage renal disease Health Condition 3: T802- Infections following infusion, transfusion and therapeutic injection
Conditions
Interventions
Intervention1: Ethanol lock: Patients in the experimental arm will receive daily instillation of 70% ethanol (randomized and concealed) into each catheter lumen for 5 days in addition to usual care wi
Sponsors
Vignesh Subramani
Eligibility
Inclusion criteria
Inclusion criteria: • Adult patients more than equal to 18 years of age • Incident hemodialysis patients with tunnelled internal jugular central venous catheters • Able to give informed consent • Documented catheter-related bloodstream infection
Exclusion criteria
Exclusion criteria: 1) Personal, cultural, or other objections to the use of alcohol as a catheter lock 2) Intolerance to alcohol 3) Patients on disulfiram 4) Pregnant/ breastfeeding patients 5) Evidence of metastatic infection such as infective endocarditis, lung abscess, septic emboli, and septic arthritis. 6) Fungal growth on blood culture 7) Catheter-related exit site or tunnel infection 8) Hemodynamically unstable Patient (shock) that warrants immediate catheter removal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients with clinical cure and catheter salvage at the end of day 6 ( on the day of completion of lock treatment )Timepoint: day 6 | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiological profile as assessed by the type of organism in the culture and its sensitivity patternTimepoint: Day 6;Preservation of the tunnelled catheter lineTimepoint: Day 30;Recurrence of catheter-related blood stream infectionTimepoint: Day 30;Safety and tolerability profile as assessed by adverse events, serious adverse events, vital signs, clinical laboratory evaluations, and physical examinations.Timepoint: Day 30;The proportion of subjects with Microbiological Eradication with negative blood cultureTimepoint: Day 6 | — |
Countries
India
Contacts
Public ContactVignesh subramani
Post graduate institute of medical education and research
Outcome results
None listed