A catheter will be introduced into the esophagus that will measure the lung and diaphragm pressure accordingly ventilator pressure will be adjusted to ease patient breathing effort

Lung and Diaphragm protective ventilation by titrating ventilatory pressures according to diaphragmatic efforts in children â?? A Randomized control trial - LAD-PROVE trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/053824

Enrollment

Registered

2023-06-13

Start date

Unknown

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J189- Pneumonia, unspecified organism

Interventions

Intervention1: Trans-pulmonary and trans-diaphragmatic pressure measurement using trans-esophageal catheter inserted via nostril: Trans-pulmonary and trans-diaphragmatic pressure measurement using tra

Eligibility

Inclusion criteria

Inclusion criteria: Critically ill children 2 years to mechanical ventilation( oxygenation index >= 4 or oxygen saturation index >= 5 with chest infiltrates

Exclusion criteria

Exclusion criteria: Neuromuscular disease Contraindications for trans-esophageal catheter insertion Active uncontrolled esophageal or gastric bleeding Traumatic brain injury Extubation within 24 hours of intubation

Design outcomes

Primary

Measure	Time frame
Duration of ventilationTimepoint: admission to 28 days	—

Secondary

Measure	Time frame
Lung stress and strain in LADPV Rate of patients achieving synchronous ventilation in LDPV Sedation requirement at LADPV Timepoint: from intubation to 28 days	—

Countries

India

Contacts

Public ContactAbinaya Kannan

All India Institute of Medical Sciences

drmrsahoo@gmail.com7893230151

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026