Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features
Conditions
Interventions
Intervention1: Ketamine IV Infusion: Ketamine Infusion - 0.5mg/kg body wt Ketamine in 100ml NS IV infusion over 40 mins thrice a week over 2 weeks
Control Intervention1: Electro-Convulsive Therapy (EC
Sponsors
Lavanya Seth
Eligibility
Inclusion criteria
Inclusion criteria: -Patients giving written informed consent or their representatives if the patients are too unwell to provide consent at the time of recruitment. HAM-D score more than or equal to 19. SSI score more than or equal to 4.
Exclusion criteria
Exclusion criteria: -Individuals diagnosed with dementia and/or mental retardation -Individuals diagnosed with seizure disorder or severe head injury, severe medical/surgical illness or electrocardiogram abnormality -Individuals having a history of schizophrenia or other psychotic disorders. -Individuals diagnosed with Depression with psychotic features -Individuals having a history of contraindications for ketamine or a history of ketamine abuse/dependence.(eg. Severe cardiovascular disease, elevated intra cranial pressure, severe liver disease, poorly controlled HTN) -History of alcohol or substance dependence (except nicotine and caffeine) in the year prior to the study -Women who are pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intravenous Ketamine will be equally efficacious & safe as ECT in treating patients with severe depression with suicidal ideation. Timepoint: At the time of enrollment in the study, at the end of 2 weeks & at the 4 weeks follow up. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ketamine will have a faster acting anti-depressant & anti-suicidal effect than ECT. Timepoint: At the time of enrollment in the study, at the end of 2 weeks & at the 4 weeks follow up. | — |
Countries
India
Contacts
Public ContactLavanya Seth
IMS & SUM Hospital
Outcome results
None listed