Health Condition 1: N978- Female infertility of other origin
Conditions
Interventions
Intervention1: Estradiol pretreatment arm: Estradiol would be started in dosage of 4mg/ day from 7 days prior to expected date of period to day 1 of the stimulation
Control Intervention1: Follicular a
Sponsors
Oasis centre for Reproductive Medicine
Eligibility
Inclusion criteria
Inclusion criteria: 1.All poor responders as defined by Poseidon criteria undergoing COS for IVF using antagonist protocol ( AFC less than or equal to 5 , AMH less than or equal to 1.2 ng/dl , unexpected poor response in previous cycle with oocytes retrieved less than or equal to 9) 2.Presence of both ovaries
Exclusion criteria
Exclusion criteria: 1. Any current or past diseases affecting ovaries or gonadotrophin or sex steroid secretion, clearance or excretion 2. Hypogonadotrophic hypogonadism 3. Premature ovarian insufficiency ( FSH > 20 or no AFCs )
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Total days of stimulation -Total dosage of FSH used -Number of oocytes retrieved -FSH to Oocyte ratio -Follicle to oocyte index -Follicular output rate -M-II rate Timepoint: 1 month | — |
Secondary
| Measure | Time frame |
|---|---|
| - Fertilisation rate - Cleavage rate - Blastulation rate - Cycle cancellation rate - Embryo utilisation rate - Implantation rate - Biochemical pregnancy rate - Clinical pregnancy rate - Miscarriage rate - Ongoing pregnancy rate - Live birth rate Timepoint: 1 year | — |
Countries
India
Contacts
Public ContactKhushboo Goel
Oasis centre for Reproductive Medicine
Outcome results
None listed