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To study the early changes in function of the heart in breast cancer patients undergoing chemotherapy using ultrasound scan of the heart

Early detection of cardiotoxicity in patients with breast cancer undergoing anthracycline-based chemotherapy using left atrial strain.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/06/053695
Enrollment
124
Registered
2023-06-09
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C50-C50- Malignant neoplasms of breast

Interventions

Intervention1: Not applicable: Not applicable Control Intervention1: Not applicable: Not applicable

Sponsors

Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients having breast cancer planned for anthracycline based chemotherapy and have normal LA and LV function at baseline.

Exclusion criteria

Exclusion criteria: 1.Patients with previously diagnosed cardiovascular disease including valvular heart disease, ischemic heart disease, previous cardiac surgery, or percutaneous interventions 2.Seriously ill patients, patients with life expectancy less than 1 year 3.Patients with poor window, unable to lie down or pain at local site prohibiting detailed echocardiographic study 4.Patients with irregular rhythms including atrial fibrillation, frequent VPCs 5.Patients undergoing other treatments like radiotherapy 6.Patients with other serious comorbidities

Design outcomes

Primary

MeasureTime frame
Left atrial strain(%)Timepoint: Before & 3, 6 , 9 months after Anthracycline-based chemotherapy

Secondary

MeasureTime frame
Other echocardiographic findingsTimepoint: Before & 3, 6 , 9 months after Anthracycline-based chemotherapy

Countries

India

Contacts

Public ContactDR GANESH P

Kasturba Medical College, Manipal Academy of Higher Education, Manipal

ganeshbmc@gmail.com9914204224

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026