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Comparison of radiofrequency ablation and cryoablation of genicular nerve to give relief of knee pain in sympomatic advanced osteoarthritis of knee

A single-centric, assessor-blinded randomized parallel group non-inferiority study to compare cryoablation vs. radiofrequency ablation of genicular nerves in advanced osteoarthritis of the knee

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/053646
Enrollment
72
Registered
2023-06-08
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee Health Condition 2: M170- Bilateral primary osteoarthritis of knee Health Condition 3: O- Medical and Surgical

Interventions

Intervention1: Cryoablation of genicular nerves: Percutaneous Cryo-ablation of genicular nerve done under C-arm or ultrasonography guidance. We compare a similar procedure of radiofrequency ablation d

Sponsors

Daradia The Pain Clinic
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Presence of chronic pain of KOA for more than two years diagnosed by NICE clinical criteria 2. Radiological diagnosis of KOA and grade 3 or more by the Kellgren and Lawrence classification 3. Average pain score of more than or equal to 5/10 in NRS 4. Failed conservative management 5. Unfit for Knee arthroplasty or unwilling for knee arthroplasty 6. Reduction of the pain by more than 50% after diagnostic genicular nerve block

Exclusion criteria

Exclusion criteria: 1. Diabetic neuropathy 2. Major psychiatric illness 3. Active inflammatory arthritis like Rheumatoid Arthritis or Spondylo Arthritis 4. Post-traumatic knee pain like meniscal injury 5. Intraarticular injection of PRP or steroid in the past three months 6. Obesity MBI > 40kg/m2 7. Gross mechanical deformity of the joint 8. Presence of local or systemic infection 9. Bleeding disorders 10. Any known contraindication of cryoneurolysis like cryoglobulinemia

Design outcomes

Primary

MeasureTime frame
Primary: Reduction of pain measured by a numeric rating scale at 6 months. Secondary outcomes: 1.Any improvement in functional capacity 2.Adverse reactions like pain at the injection site or any other adverse reactionsTimepoint: Pain and other improvement at 6 months—

Secondary

MeasureTime frame
1. Any improvement in functional capacity 2. Adverse reactions like pain at the injection site or any other adverse reactionsTimepoint: 6 months follow up—

Countries

India

Contacts

Public ContactGautam Das

Datta Meghe Institute of Higher Education & Research

dramolsingam@gmail.com9422538005

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026