FindTrial
Sign In

To observe the effect on cough response during extubation and post-extubation airway morbidity in patients undergoing elective surgery via endotracheal tube cuff inflation with lignocaine, ketamine and dexamethasone in comparison to normal saline:a randomized controlled trial

Effect of endotracheal tube cuff inflation with lignocaine, ketamine and dexamethasone in comparison to normal saline on cough response during extubation and post-extubation airway morbidity in patients undergoing elective surgery: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/053609
Enrollment
208
Registered
2023-06-07
Start date
Unknown
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ketamine: Endotracheal cuff inflation with Ketamine 20mg in 3ml at the time of intubation and removed during extubation when surgery gets over at the time of cuff deflation Interventio

Sponsors

AIIMS Bathinda
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: aged 18-60 years old, BMI American society of Anesthesiologists class I-II

Exclusion criteria

Exclusion criteria: History of Smoking-( >10 pack years) COPD Patient refusal Asthma Laryngotracheal disease Any respiratory tract infection during last 6 weeks Difficult intubation( >2 attempts of laryngoscopy) Head and neck surgeries Laparoscopic surgeries History of increased intracranial pressure or intraocular pressure History of known allergy to any study drugs

Design outcomes

Primary

MeasureTime frame
To compare the effect of intra cuff inflation with lignocaine,ketamine and dexamethasone with normal saline on cough response during extubation which is the number of times the patient coughs during first 5 minutes of extubation.Timepoint: Coughing during first 5 minutes of extubation after the completion of the surgery.—

Secondary

MeasureTime frame
To compare the effect of intra-cuff inflation with lignocaine, ketamine, and dexamethasone with normal saline on 1) Post extubation sore throat Timepoint: 1 hour, 2 hour, 4 hour and 24 hour;To compare the effect of intra-cuff inflation with lignocaine, ketamine, and dexamethasone with normal saline on 3)Hemodynamic changes (BP, HR, Sp02)Timepoint: 5 minutes, 10 minutes and 15 minutes.;To compare the effect of intra-cuff inflation with lignocaine, ketamine, and dexamethasone with normal saline on 4)Post extubation hoarseness of voiceTimepoint: 18 hour and 24 hour;To compare the effect of intra-cuff inflation with lignocaine, ketamine, and dexamethasone with normal saline on 5) Post extubation dysphagiaTimepoint: 18 hour and 24 hour;To compare the effect of intra-cuff inflation with lignocaine, ketamine, and dexamethasone with normal saline on 2) Post-operative nausea vomitingTimepoint: 1 hour, 2 hour, 4 hour and 24 hour—

Countries

India

Contacts

Public ContactUtkarsh

All India Institute of Medical Sciences, Bathinda

doctorjyotisharma@yahoo.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026