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Clinical study of effect of IV lignocaine on arterial blood pressure and consumption of IV fentanyl as an opioid sparing analgesic and consumption of isoflurane in maintaining the depth of anaesthesia measured by entropy during surgery in patients undergoing laparoscopic cholecystectomy

EFFECT OF LIGNOCAINE ON ARTERIAL BLOOD PRESSURE AND INTRAOPERATIVE ISOFLURANE AND FENTANYL CONSUMPTION IN LAPAROSCOPIC CHOLECYSTECTOMY -ENTROPY BASED RANDOMIZED CONTROL TRIAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/053601
Enrollment
56
Registered
2023-06-07
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Lignocaine: IV Lignocaine 1.5mg/kg bolus followed by 2mg/kg/hour IV infusion given vitals noted from the time of preinduction every 5 mins till the end of surgery of duration 2hours. Co

Sponsors

Vijayanagar institute of medical sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age group of 20 years to 60 years of either gender. American Society of Anesthesiologists (ASA) physical status I to II Patients undergoing elective laparoscopic surgeries lasting upto 2hours.

Exclusion criteria

Exclusion criteria: Refusal of patient for the clinical trial. Patients with history of severe Hepatic, Renal, Cardiac and neurological disease ,diabetes ,Hypertension, obesity (Body mass index >30kg/m2). Patients on chronic use of sedative medications Allergy to local anaesthetics -lignocaine Inability to comphrehend pain assessment.

Design outcomes

Primary

MeasureTime frame
Changes in Mean Arterial Blood pressure 5 mins after pneumoperitoneum during laparoscopic cholecystectomy.Timepoint: 5 minutes after pneumoperitoneum till the end of surgery.—

Secondary

MeasureTime frame
Changes in systolic blood pressure diastolic blood pressure heart rate & isoflurane consumption cumulative dose of rescue analgesia & severity of pain and postoperative nausea and vomiting and level of sedation and length of stay in PACUTimepoint: From the arrival of patient to operation theatre till patients stay in PACU—

Countries

India

Contacts

Public ContactDr Parimala

Vijayanagar institute of medical sciences

rashmibirajdar33@gmail.com7847033549

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026