Health Condition 1: E440- Moderate protein-calorie malnutrition
Conditions
Interventions
Intervention1: Finger millet based nutritional intervention: 50 gms of Intervention (in the form of a gruel or ladoo) would be given to each enrolled child for 5 days a week for 8 weeks. The feeding
Sponsors
ICMR National Institute of Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: 1.Only children aged 30 to 59 months (below 5 years) will be enrolled in the study 2.Children detected for the first time (primary) with Moderate acute malnutrition (MAM) having weight-for-height z-score (WHZ) between -2 and -3 below the median of the WHO child growth standards. These are children who have never been previously diagnosed or received any treatment for undernutrition (based on anthropometry records maintained at Anganwadi centers). 3.For Control or Apparently Healthy (AH) children, weight-for-height z-score (WHZ) should be between -1 and +1 of the medians of the WHO child growth standards. 4.They also should never have been previously diagnosed or received any treatment for undernutrition
Exclusion criteria
Exclusion criteria: 1 Any congenital/acquired disorder affecting growth i.e. known case of trisomy-21 or cerebral palsy 2.Children having Severe anemia ( 3.Children with dietary caloric insufficiency (as assessed through 24-hour dietary recall method) will be excluded from the study 4.History of diarrhea, severe acute respiratory illness (SARI) or any other serious ailment requiring hospital admission within a period of at least four weeks before fecal sample collection will not be included in the study 5.Subjects who have consumed or will need to consume any antibiotics, probiotics, prebiotics, or any other products capable of drastically altering the gut microbiome, within a period of at least four weeks before enrolment in the study or anytime during the trial, will be excluded from the study 6.Receiving concurrent treatment for another condition 7.Requires use of medication or undergoes any medical procedure for treatment of any infection/condition during the feeding trial or follow up period of up to 6 months, that may alter the microbiota profile of the gut, will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in gut microbiota structure and function Timepoint: 0 days 30 days 60 days 120 days 180 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Improved weight gainTimepoint: 0 days 30 days 60 days 120 days 180 days | — |
Countries
India
Contacts
Public ContactJ J Babu Geddam
ICMR-National Institute of Nutrition
Outcome results
None listed