To compare postoperative analgesia by adding additive intrathecal buprenorphine to 0.75% hyperbaric ropivacaine in lower segmental caesarean section.

BUPRENORPHINE AS AN ADJUVANT TO ROPIVACAINE IN SPINAL ANAESTHESIA FOR LOWER SEGMENT CAESAREAN SECTION: A COMPARATIVE PROSPECTIVE RANDOMISED STUDY

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/053571

Enrollment

122

Registered

2023-06-06

Start date

Unknown

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Intrathecal 0.75%hyperbaric ropivacaine 2.2 ml with 0.1ml buprenorphine(30mcg): Under strict sterile aseptic precaution, after local infiltration with 2% lignocaine, sub-arachnoid block

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA I to II Patients Female patients.2. Aged between 20 to 60 years.3. Normal liver and renal function test, Coagulation profile.4. Undergoing Lower Segment Caesarean Section Surgery.

Exclusion criteria

Exclusion criteria: 1. Patients with history of allergy to local anaesthetics.2. Patients with history of mental disorders.3. Patient Refusal.4. Morbid obesity, Coagulopathy and significant cardiovascular respiratory, renal, hepatic or metabolic diseases or CNS disorders.5. Infection at site of procedure

Design outcomes

Primary

Measure	Time frame
The post operative analgesic efficacy of intrathecal/ subarachnoid buprenorphine with 0.75% hyperbaric Ropivacaine is better than intrathecal/ subarachnoid 0.75% hyperbaric Ropivacaine in lower segment caesarian sectionsTimepoint: VAS score in post operative period at 1 hour , 2 hour , 4 hours , 8 hours , 12 hours and 24 hours post surgery	—

Secondary

Measure	Time frame
To assess the following characteristics. 1. Sensory and motor blockade. 2. Effective analgesic time. 3. Hemodynamics. 4. Complication rates. 5. Post operative analgesia using Visual Analog Scale [ VAS] Timepoint: Intraoperative and postoperative period 24 hrs post surgery	—

Countries

India

Contacts

Public ContactLini Rajan

Rajarajeswari Medical College and Hospital

sudheerramegowda81@gmail.com9741117754

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026