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Study to estimate mean effect site concentration of propofol required for induction of anesthesia using target control infusion.

Comparative study to estimate the mean effect site concentration of propofol at induction of anesthesia using two pharmacokinetic models of target control infusion (Marsh & schnider)- A rondomised double blind study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/053556
Enrollment
80
Registered
2023-06-05
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Marsh model of target control infusion: Anesthesia is induced and maintained by Propofol using marsh model of target control infusion till end of surgery. Intervention2: Schnider model

Sponsors

Shri Dharmasthala majunatheshwara college of medical sciences and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex age between 18 to 60 years. All elective cases, requiring general anesthesia, with duration of surgery more than 1 hrs. ASA I and II patients with BMI 24 ± 5

Exclusion criteria

Exclusion criteria: Patients who had neurologic or psychiatric illness. Patients having hepatic disorders. Pregnant females, any contraindication to propofol. patients with IHD. Patients withDifficult airway

Design outcomes

Primary

MeasureTime frame
The mean effect site concentration of propofol at induction in Indian population is lesser than the western populationTimepoint: from start of infusion to loss of response to verbal command—

Secondary

MeasureTime frame
Faster induction in schnider modelTimepoint: from the start of infusion to loss of response to verbal command;total propofol requirement is higher in marsh modelTimepoint: Form the start of infusion to end of infusion—

Countries

India

Contacts

Public ContactNayana M S

Shri Dharmasthala Manjunatheshwara college of medical sciences and hospital

kakkodravi@yahoo.co.in9740183281

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026