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A Study on the Comparison of Effects in Lower Body Surgeries using A Local Anesthetic with two different Adjuvants

Comparative study of epidural dexmedetomidine and buprenorphine as adjuvant to Ropivacaine in lower limb orthopaedic surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/053534
Enrollment
60
Registered
2023-06-05
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: Dexmedetomidine as adjuvant to Ropivacaine in Epidural anaesthesia for lower limb surgeries Intervention2: Dexmedetomidine: To study the effect of 50 microgram Dexmedet

Sponsors

Gulbarga institute of medical sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists status I and II Adult patients of age group between 18-60 years Patients undergoing for elective lower limb Orthopedic surgeries BMI between 18.5kg/m2 to 29.9kg/m2

Exclusion criteria

Exclusion criteria: Any bleeding disorders and patients on anticoagulants Neurological and musculoskeletal diseases Local infection at the epidural site Allergic history to local anaesthetics in previous surgeries Pregnant females

Design outcomes

Primary

MeasureTime frame
To compare the onset and duration of sensory and motor blockade after adding Dexmedetomidine and Buprenorphine as adjuvant to Ropivacaine in epidural anaesthesia for lower limb orthopaedic surgeries. To compare the duration of analgesia in both the groups.Timepoint: Onset of sensory and motor blockade to be assessed every minute after giving the drug. Duration of sensory and motor blockade to be assessed every 30 minutes after onset of blockade. Duration of analgesia to be assessed starting 2-3 hours after administration of drug till the patient complaints of pain

Secondary

MeasureTime frame
1.To study the haemodynamic parameters in both groups 2.To study the adverse effects in both groups.Timepoint: 1.Intraoperative 2.intraoperative and post operative

Countries

India

Contacts

Public ContactDrAswin M S

Rajiv Gandhi University of Health Sciences

drjagadish.mb@gmail.com9886287016

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026