Health Condition 1: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: Right lobe liver biopsy: EUS-LB of right lobe using wet suction technique as mentioned below:
i. Patients undergoing EUS-LB will receive moderate sedation using midazolam or nalbuphine
Sponsors
Jayanta Samanta
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients requiring liver biopsy 2. Informed consent obtained from the patient 3. Patients >18 years old
Exclusion criteria
Exclusion criteria: 1. Unable to obtain informed consent from the patient 2. Medically unfit for sedation 3. Pregnant patient 4. Presence of a mass lesion in the liver requiring biopsy visualized on cross-sectional imaging 5. Irreversible coagulopathy as determined by platelet count 1.5 6. Unable to stop anticoagulation or anti-platelet therapy for 5 days prior to the procedure 7. Hemophilia 8. Presence of an alternative etiology for elevated liver tests seen during liver biopsy, e.g. biliary obstruction during EUS examination 9. Suspected or proven malignant liver disease. 10. severe cardiovascular and pulmonary diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of complete portal tracts (CPT)Timepoint: At procedure. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Post processing maximum (or aggregate) specimen length 2. Length of the longest specimen 3. Adequacy of tissue sample 4. Rates of specimen adequacy (whether pathological diagnosis is reached or not) Timepoint: At procedure;5. Assessment of pain scores (subjective & objective) 6. Pain medication requirement: use of narcotics/analgesics in both arms, post-procedure Timepoint: Immediate post procedure, 1 hr., 12 hr., 24 Hr.;7. Rate of adverse eventsTimepoint: Immediate post procedure, 24 hr, 1 week | — |
Countries
India
Contacts
Public ContactJayanta Samanta
Post Graduate Institute of Medical Education and Research, Chandigarh
Outcome results
None listed