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A prospective trial to study the trend of markers of cerebral of cerebral oxygenation and metabolism in patients undergoing clipping of cerebral aneurysm under total intravenous anaesthetic techniques and inhalational anaesthetic technique

Evaluation of markers of cerebral oxygenation and metabolism in patients undergoing clipping of cerebral aneurysm under Propofol based total intravenous anaesthesia versus Sevoflurane based inhalational anaesthesia: A prospective randomized trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/053493
Enrollment
50
Registered
2023-06-02
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: 1. Jugular venous oxygenation saturation catheter 2. Randomisation of study population into two groups- sevoflurane based inhalational anesthesia and propofol based total intravenous an

Sponsors

ISNACC
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: -ASA class I- IV (class IV due to SAH) -Both gender -Age 18-65 years, undergoing clipping of cerebral aneurysm in the neurosurgery operation theatre. -informed consent from patient or legal heir

Exclusion criteria

Exclusion criteria: -ASA class III,IV (due to other systemic comorbidities), V -Age 65 years -Severe or uncompensated cardiovascular, renal, hepatic or endocrine disease -Pregnancy, postpartum, lactating females -Drug allergy to Propofol or Fentanyl -Refusal to consent by patient or legal heir -Patients who are intubated and on mechanical ventilation -Emergency surgery

Design outcomes

Primary

MeasureTime frame
1.To compare changes in the lactate oxygen index in patients undergoing clipping of cerebral aneurysm under propofol-based total intravenous anaesthesia and sevoflurane based inhalational anesthesia 2.To compare the changes in the jugular venous oxygen saturation in patients undergoing clipping of cerebral aneurysm under propofol based intravenous anesthesia group and sevoflurane based inhalational anesthesia groupTimepoint: The time points for estimation of these parameters are: a)at baseline b) after temporary clipping if applicable c) after permanent clipping d) 6 hours after extubation—

Secondary

MeasureTime frame
The postoperative incidence of delayed cerebral ischemia along with short and long term outcome Timepoint: 1)Modified rankin score at discharge, at 6 weeks, and at 12 weeks 2) Glasgow outcome score at 12 weeks—

Countries

India

Contacts

Public ContactDr Ajay Prasad Hrishi P

Sree Chitra Tirunal Institute of Medical Sciences and Technology

drajay@sctimst.ac.in9495239765

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026