Comparing pain relief during & after laparoscopic surgeries by using multiple approaches to pain management using narcotic free medications

Impact of opioid-free anaesthesia using multimodal approach on peri-operative pain & patient recovery in laparoscopic surgeries: A prospective randomised comparative study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/053482

Enrollment

Registered

2023-06-02

Start date

Unknown

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K352- Acute appendicitis with generalized peritonitis Health Condition 2: K800- Calculus of gallbladder with acutecholecystitis Health Condition 3: N938- Other specified abnormal uterine and vaginal bleeding Health Condition 4: K469- Unspecified abdominal hernia without obstruction or gangrene

Interventions

Intervention1: Opioid free anaesthesia: Patients will receive Tablet Pregabalin 150mg 1-hour prior induction. Intravenous Ketorolac 30mg, Magnesium sulphate 30 mg/kg, Lidocaine 1.5mg/kg, Dexamethasone

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA I and II patients of either sex. 2. Patients aged between 18 to 70 years 3. Patients undergoing elective laparoscopic abdominal surgeries.

Exclusion criteria

Exclusion criteria: 1. Patientâ??s refusal. 2. Pregnant and lactating women, patients with epilepsy and mentally unstable patients. 3. ASA 3 and ASA 4 patients. 4. Allergy to study drugs 5. Patient on opioids, sedatives, beta-blockers 6. Coagulopathy 7. Infection at the site of block 8. Neuroâ??psychiatric disorders 9. Hepatic and renal dysfunction

Design outcomes

Primary

Measure	Time frame
To compare opiod free anaesthesia technique with opioid based anaesthesia on peri-operative pain relief.Timepoint: Intraoperative pain will be assessed using hemodynamic parameters from the time of induction till end of surgery. Postoperative pain will be assessed using 0 to 10 visual analogue score at 5, 15, 30, 60 mins, 2, 4, 6, 8, 10, 12, 16, 20, 24 hrs.	—

Secondary

Measure	Time frame
Suppression of hemodynamic responses during surgery. Perioperative opioid consumption. Duration of analgesia & time for first rescue analgesic request. Postoperative nausea & vomiting. Sleep quality. Patient satisfaction. Adverse effects if any.Timepoint: Total opioid consumption intraoperatively will be recorded. Duration till first rescue analgesic request & total analgesic consumption in 24 hours will be noted. Postoperative nausea, vomiting, sleep quality and adverse events during first 24 hours will be recorded. Patient satisfaction will be assessed according to comfort VAS scale.	—

Measure

Time frame

Suppression of hemodynamic responses during surgery. Perioperative opioid consumption. Duration of analgesia & time for first rescue analgesic request. Postoperative nausea & vomiting. Sleep quality. Patient satisfaction. Adverse effects if any.Timepoint: Total opioid consumption intraoperatively will be recorded. Duration till first rescue analgesic request & total analgesic consumption in 24 hours will be noted. Postoperative nausea, vomiting, sleep quality and adverse events during first 24 hours will be recorded. Patient satisfaction will be assessed according to comfort VAS scale.

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Countries

India

Contacts

Public ContactDr S Rangalakshmi

Rajarajeswari Medical College and Hospital

ahshwetha@gmail.com9449795180

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026