Health Condition 1: M057- Rheumatoid arthritis with rheumatoid factor without organ or systems involvement Health Condition 2: M057- Rheumatoid arthritis with rheumatoid factor without organ or systems involvement
Conditions
Interventions
Intervention1: Doxycycline, Linezolid, Lactobacillus, Bifidobacteria (plus SOC): Once the diagnosis of rheumatoid arthritis is confirmed, the patients will be followed up at 6 and 12 weeks after givin
Sponsors
Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18yrs or more on the day of registration 2. Subjects diagnosed to be patient of Rheumatoid Arthritis according to 2010 ACOG-EULAR classification criteria who are treatment naive 3. Subjects willing to give signed informed consent 4. Subjects not on any anti-rheumatic treatment or DMARDs other than occasional NSAIDs
Exclusion criteria
Exclusion criteria: 1. Subjects who have received treatment for RA anytime or antibiotics in the last 6 weeks 2. Subjects with other inflammatory diseases which may act as confounders 3. Any significant co-existing/incapacitating chronic illness 4. Subjects on corticosteroids or any other immunosuppressive therapy 5. Subjects who are pregnant or reproductive couples who have intention of pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in DAS 28 CRP at 6 and 12 weeksTimepoint: 6 and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Any untoward effect or hypersensitivity reactionTimepoint: At 1 and 2 week | — |
Countries
India
Contacts
Public ContactDrSusmita Das
Institute of Medical Sciences, BHU
Outcome results
None listed