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Effect of feeding of first milk in premature babies on time taken to reach full feeds

Impact of Colostrum oral immunotherapy in preterm neonates less than/equal to 30 weeks on time to achieve full enteral feeds

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/06/053431
Enrollment
48
Registered
2023-06-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P84- Other problems with newborn

Interventions

Intervention1: Colostrum oral immunotherapy: 0.2ml of Mothers own colostrum will be applied orally using 1ml syringe to paint each cheeks starting within 12 hrs of life till first 96 hrs of life Contr

Sponsors

Unsponsored
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All very Preterm babies born at or below 30 weeks on room air or requiring any mode of invasive/ non-invasive respiratory support, and no/one inotrope

Exclusion criteria

Exclusion criteria: 1.Babies requiring >2 inotropes. 2.Lethal congenital anomalies. 3.Gastrointestinal anomalies/ bilious or blood stained aspirates. 4.Baby born to seropositive mother. 5.Babies born to critically ill mothers unable to provide colostrum.

Design outcomes

Primary

MeasureTime frame
time to reach full enteral feeds of 150ml/kg/day in preterm neonates 30 weeks admitted to NICUTimepoint: At baseline, at 4 weeks of life—

Secondary

MeasureTime frame
1.Feed intolerance before reaching full enteral feeding. 2.Spontaneous Intestinal Perforation before reaching full enteral feeds. 3.Microbiologically confirmed late-onset infection. 4.NEC (Bellâ??s stage 2 or 3) before reaching full enteral feeds. 5.NEC any time during hospital stay. 6.Ventilator associated pneumonia. 7.Bronchopulmonary dysplasia. 8.Weight gain during hospital stay. 9.Intraventricular haemorrhage grade 2 or higher. 10.Periventricular leukomalacia. 11.ROP requiring treatment. 12.Length of hospital stay. 13.Adverse events like choking, bradycardia, desaturation. 14.Mortality. Timepoint: from day of life 1 to hospital discharge—

Countries

India

Contacts

Public ContactDr Akshaya Krishna D S N

Lokmanya Tilak Municipal General Hospital and Medical College

drswatimanerkar@gmail.com9769997968

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026