Use of different doses of magnesium sulphate nebulization as an adjunct in general anaesthesia.

Dose ranging and safety of nebulized magnesium sulphate as an adjunct in general anaesthesia- a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/06/053414

Enrollment

120

Registered

2023-06-01

Start date

Unknown

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium sulphate: 1.Group 1– will receive preoperative nebulization with 20 mg/kg of magnesium sulphate, for 15 minutes in sitting position prior to shifting to OT 2.Group 2– will rec

Eligibility

Inclusion criteria

Inclusion criteria: 1)Elective surgeries (of 2)American Society of Anaesthesiologists (ASA) physical status I and II

Exclusion criteria

Exclusion criteria: 1)Predicted difficult airway 2)Obese patients (BMI >30 meter square) 3)Subjects on antihypertensive medication. 4)Pregnancy 5)Known allergy to magnesium sulphate 6)Neuromuscular disorder 7)Renal failure 8)Heart block

Design outcomes

Primary

Measure	Time frame
Mean arterial pressure(MAP) and Heart rate (HR)Timepoint: 3 Minutes	—

Secondary

Measure	Time frame
1)Mean arterial pressure (MAP) and Heart rate (HR) at 1,5,7 minutes after intubation. 2) Propofol dose requirement at induction. 3) Time of requirement of rescue analgesic. 4) Incidence of postoperative sore throat in 24 hours. 5) Incidence of postoperative nausea and vomiting upto 24 hours.Timepoint: 1,5,7 MINUTES	—

Countries

India

Contacts

Public ContactDr Amit Pradhan

Kalinga Institute Of Medical Sciences

amitpdear@gmail.com9437191002

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026