Health Condition 1: - Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Hypothermic oxygenated machine perfusion after static cold preservation: The Vivosmart platform was used for ex situ machine perfusion of the liver. The device enables pressure-control
Sponsors
Mohamed Rela
Mauricio Carvalho
Eligibility
Inclusion criteria
Inclusion criteria: Donor criteria: 1.Any living liver donor used for transplantation at Dr. Rela institute within the study period 2.Any type of donation surgery (open, robotic,..) 3.Any liver lobe (right, left) 4.GRWR Recipient Criteria: 1.Adult recipient (=18years of age) of living related liver transplantation at Dr. Rela Institute 2.Primary liver transplantation 3.Donor-recipient ABO compatible or incompatible 4.Lab MELD of =25points 5.Recipient with any chronic liver disease with or without cirrhosis with or without liver tumour (HCC, or other) 6.Consented recipient
Exclusion criteria
Exclusion criteria: 1.Recipient listed due to acute or subacute liver failure 2.Recipient listed for retransplantation 3.Recipients with known grade III or IV portal vein thrombosis 4.Recipients with combined transplantation (e.g., liver + kidney, liver + any other organ) Recipients with lab MELD >25points 5.Recipients with sepsis (ICU requirement) at the time of transplantation 6.Recipients with ventilation at time of transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Endpoint: SFSS (Small for size Syndrome) , EAD (Early Allograft Dysfunction )Timepoint: 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Need for intraoperative flow modulation (surgical: Splenic Artery Ligation, Splenic Embolisation, Porto caval-shunt, pharmacological…) or postop interventions 2.Intraoperative RBC, FFP trasnfusions 3.Lactate end of Orthotopic Liver Trasnplantation(OLT), pharmacological support end of OLT 4.HOPE perfusate: FMN, NADH, oxygenation 5.ICU, hospital stay 6.Transaminases 1st week including peak 7. INR 12 and 24hrs and day 7 after OLT 8.Lactate 6, 12, 24hrs after OLT 9.Bilirubin day 7 10.AKI rate, need for dialysis/CVVH and duration 11.Pharmacological support 12.Biliary, vascular com1plications 13.Sepsis/infection 14.Major complication & CCI(comprehensive Complication Index in hospital, 3m, 12m after OLT 15. Graft/patient survival within 1y after OLT Timepoint: in hospital, 3, 6, 9, 12 months | — |
Countries
India
Contacts
Public ContactSandeep Jasper Rajasekhar
Dr Rela Institute and Medical Centre
Outcome results
None listed