Health Condition 1: C71- Malignant neoplasm of brain Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Gabapentin: Oral Gabapentin as per body weight-
10-20 kg- 100 mg
20-30 kg- 150 mg
30-40 kg- 200 mg
40-50 kg- 250 mg
50-60 kg- 300 mg
(each patient receiving a dose of minimum 5mg/kg i
Sponsors
Shruti Pandey
Eligibility
Inclusion criteria
Inclusion criteria: all children under 18 yrs will be considered provided they do not fall under the exclusion criteria
Exclusion criteria
Exclusion criteria: Signs and symptoms of raised ICP Children on nasogastric tube feeds Children already on pregabalin or gabapentin preoperatively Children having known allergy to gabapentin or pregabalin Children with renal dysfunction Children with body weight 60 kg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in the intraoperative fentanyl requirement in the two groupsTimepoint: at the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Ease of parental separationTimepoint: Before shifting patient to OT;Pre-operative sedation scoreTimepoint: Before shifting patient to OT;Intraoperative hemodynamic response to noxious stimuliTimepoint: pin insertion, skin incision, dural incision, dural closure, skin closure and extubation;Number of patients who remained intubated at the end of 24 hrsTimepoint: 24 hrs after surgery;Episodes of POV in first 24 hrsTimepoint: 24 hrs after surgery;Pain scores in first 24 hoursTimepoint: 2,4,6,12,24 hrs after surgery;Seizure episodes in first 24 hoursTimepoint: 24 hrs after surgery;Need for rescue analgesia in first 24 hrsTimepoint: 24 hrs after surgery;Nursesâ?? satisfaction scoreTimepoint: 24 hrs after surgery;Patient compliance with study medicationTimepoint: at time of drug administration | — |
Countries
India
Contacts
Public ContactShruti Pandey
All India Institute of Medical Sciences
Outcome results
None listed