Health Condition 1: E111- Type 2 diabetes mellitus with ketoacidosis
Conditions
Interventions
Intervention1: INTRAVENOUS THIAMINE WITH STANDARD DKA TREATMENT: intravenous thiamine 200 MG in 100 mL Normal Saline over 30 minutes once a day for 3 days in addition to standard DKA management
Cont
Sponsors
Academic clinical trail at govt hospital
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients aged 18 years or older giving written informed consent. Patients admitted to the hospital with a diagnosis of diabetic ketoacidosis. {Defined as Clinical Signs and Symptoms with Hyperglycemia ?250 mg/dL with metabolic acidosis with high anion gap [S. Bicarbonate =15 mEq/L, anion gap ?12 mEq/L, Blood PH ?7.3] with Urine ketones (qualitative) Positive}1
Exclusion criteria
Exclusion criteria: Patients with history of alcohol abuse or dependence . Patients who are pregnant or breastfeeding . Patients with diagnosis of shock and acute or chronic kidney disease. Repeat episode of DKA in previously enrolled patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in time to resolution between the intervention group and active control groupTimepoint: Baseline, 3 days or earlier if DKA resolves | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in morbidity and mortalityTimepoint: Baseline, 3 days, time of discharge | — |
Countries
India
Contacts
Public ContactALISHA KHAN
UCMS and GTB Hospital
Outcome results
None listed