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Differences in symptoms and cognitive profiles of schizophrenia patients having tobacco dependence versus those not having tobacco dependence

An observational study comparing symptom profiles, medication profile and socio occupational functioning in patients of schizophrenia with and without comorbid tobacco dependence in a tertiary care hospital in South India

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/05/053196
Enrollment
300
Registered
2023-05-29
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F25- Schizoaffective disorders Health Condition 2: F20- Schizophrenia

Interventions

None listed

Sponsors

Department of Psychiatry KMC Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Criteria for patients with schizophrenia who use tobacco in dependence pattern 1. Patients meeting the diagnostic criteria for Schizophrenia according to the International Classification of Disease 10 DCR; diagnosed for at least 2 years 2. Patients meeting criteria for tobacco dependence syndrome 3. Stable antipsychotic dose for last 3 months 4. Patients willing to give informed consent in either English, Hindi or Kannada 5. Patients between the ages of 18-60 years Criteria for patients with schizophrenia who donâ??t use tobacco 1. Patients meeting the diagnostic criteria for Schizophrenia according to the International Classification of Disease 10 DCR; diagnosed for at least 2 years 2. Patients who have never used tobacco in dependence pattern and currently not using tobacco in any form 3. Stable antipsychotic dose for last 3 months 4. Patients willing to give informed consent in either English, Hindi or Kannada 5. Patients between the ages 18-60 years

Exclusion criteria

Exclusion criteria: 1. Patients with comorbid neurological disorders (for example. Stroke, head injury, Parkinsonâ??s disease, or neurodegenerative disorders) 2. Patients with uncontrolled medical comorbidities 3. Other substance use in dependence pattern

Design outcomes

Primary

MeasureTime frame
1.Brief Psychiatric Rating Scale (BPRS) 2.Negative Symptom Assessment Scale â?? 4 (NSA-4) 3.A Brief Cognitive Assessment Tool for Schizophrenia (B-CATS) 4.Socio Occupational Functioning Scale (SOFS) 5.Simpson Angus Scale (SAS)Timepoint: One time evaluation at the time of interview; cross-sectional evaluation

Secondary

MeasureTime frame
Themes generated during in-depth interview for understanding the meaning of tobacco dependence in this population as part of the qualitative aspect of the study Timepoint: One time evaluation at the time of interview; cross-sectional evaluation

Countries

India

Contacts

Public ContactDr Rajeshkrishna Bhandary P

Kasturba Medical College Manipal

rajesh.kbp@manipal.edu9844542567

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026