Health Condition 1: D015- Carcinoma in situ of liver, gallbladder and bile ducts
Conditions
Interventions
Intervention1: Radiolabelled microspheres: Indegenously prepared Microspheres radiolabelled with beta emitting therapeutic radionuclides produced within our country (BARC INDIA) will be used be used.
Sponsors
Departmental project
Department of Nuclear Medicine initiated project
Eligibility
Inclusion criteria
Inclusion criteria: · Patients older than 18 years of age · Confirmed diagnosis of HCC with no previous specific treatment · Has at least one measurable (one-dimensional) tumor >5cm · Patients with or without portal vein thrombosis · Have acceptable biological test reports · Patients In good general condition (Karnofsky performance status of more than 70) · Ready to give written informed consent for the protocol approved by IEC
Exclusion criteria
Exclusion criteria: · Pregnancy or lactation · Poor liver function (Child score C) · Extra-hepatic metastasis · Severe chronic pulmonary disease · Any other serious illness · An overall survival expectancy of less than 1 month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Response in the form of tumor size reduction or appearance of necrosis with in the treated lesion as per modified response evaluation criteria. 2. Reduction in elevated liver enzymes 3. Decreased level of AFP (if raised) Timepoint: 8-12 weeks post procedure | — |
Secondary
| Measure | Time frame |
|---|---|
| improved quality of life study survival benefitTimepoint: every 6 month followup | — |
Countries
India
Contacts
Public ContactDr Jaya Shukla
Post Graduate Institute of Medical Education and Research
Outcome results
None listed