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Comparing efficacy of two medicines in treating the increase in heart rate and blood pressure that occurs during laparoscopic surgery.

Role of oral Ivabradine premedication vs oral clonidine in attenuation of hemodynamic response in laparoscopic surgeries under general anaesthesia- A Randomized controlled study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/05/053098
Enrollment
82
Registered
2023-05-24
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere

Interventions

Intervention1: ivabradine: Ivabradine is a newer cardioprotective drug, a selective blocker of If (funny channels located in the SA node) current, with a distribution half-life of 2 hrs and effective

Sponsors

Dr.Darryl baby
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18-50 years. 2. American society of Anesthesiologists physical status [ASA] grade I and II. 3. Elective laparoscopic surgeries of less than 4 hours in duration.

Exclusion criteria

Exclusion criteria: 1. Patients with a baseline Heart rate of less than 65 bpm and baseline blood pressure of 2. Patients with cardiac comorbidities (IHD, VHD, CCF, Arrythmias, pacemaker dependent). 3. Patients on Beta blockers, Verapamil or Diltiazem. 4. Pregnant patients. 5. Patients with BMI > 30 KG/M2. 6. Anticipated difficult airway. 7. Patients with uncontrolled hypertension ( >140/90mm of Hg).

Design outcomes

Primary

MeasureTime frame
The primary outcome we are expecting is reduction in blood pressure and heart rate after giving two premedications ivabradine and clonidine and to compare the efficacy by percentile measurement.Timepoint: .5 min before induction, 3 minutes after induction â?¢ 1 minute, 3 minutes, 5 minutes and after laryngoscopy and intubation. â?¢ At surgical incision: 1 minute, 3 minutes, 5 minutes after surgical incision. â?¢At insufflation of CO2, 1 minute and every 3 minutes till desufflation â?¢ At 1 minute interval from the time of reversal to 5 minutes after extubation.—

Secondary

MeasureTime frame
To compare the effect of ivabradine and clonidine administers as premedication on the recovery profile in these patients.Timepoint: Expecting similar reduction in blood pressure,heart rate post surgery in recovery room upto 1 hour post extubation and to also record any adverse effects of premedicaions given and to check whether it has improved recovery status by assessing pain score.—

Countries

India

Contacts

Public ContactDeepa Baskaran

St Johns National Academy of Health Sciences

anesdeepa@gmail.com9731245827

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026