Health Condition 1: G09- Sequelae of inflammatory diseasesof central nervous system
Conditions
Interventions
Intervention1: nil: nil
Sponsors
Science and Engineering Research Board( Core Research Grant)
Eligibility
Inclusion criteria
Inclusion criteria: All patients (i) Diagnosed to have Guillain Barre syndrome based on the National Institute of Neurological Disorders and Stroke (NINDS) criteria and Brighton level of certainty one or two. (ii)Undergoing a minimum of 5 cycles of Therapeutic plasma exchange will be recruited under 2 groups. Group A: Patients with Guillain Barre syndrome requiring mechanical ventilation and TPE Group B: Patients with Guillain Barre syndrome requiring TPE, and not requiring mechanical ventilation and ICU care
Exclusion criteria
Exclusion criteria: Age less than 18 and more than 65 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of endothelial glycocalyx disruption in patients with Guillain Barre Syndrome undergoing therapeutic plasma exchange therapy.Timepoint: At baseline, after 1st cycle of TPE, after 5th cycle of TPE and at 72 hours after final TPE | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical methods of endothelial activation can be regularly implemented in routine practice before deciding on to TPE therapy. 2. Replacement fluid during TPE can be standardised 3. Based on the extent of endothelial disruption appropriate treatment therapy with either TPE or Immunoglobilin therapy can be chosen in critically ill patients admitted at ICU requiring mechanical ventilation.Timepoint: At baseline, after 1st cycle of TPE, after 5th cycle of TPE and at 72 hours after final TPE | — |
Countries
India
Contacts
Public ContactShwethashri KR
National Institute of Mental Health and Neurosciences
Outcome results
None listed