Health Condition 1: I60- Nontraumatic subarachnoid hemorrhage
Conditions
Interventions
Intervention1: Dexmedetomidine: Intravenous Dexmedetomidine infusion @ 0.7 μg/kg/hr intraoperatively during surgery
Control Intervention1: Placebo (Normal saline): intravenous infusion of Normal sali
Sponsors
AIIMS, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: All ASA 1/II patients who report within 5 days of ictus and provide informed written consent.
Exclusion criteria
Exclusion criteria: Refusal of consent, ASA grade III-V, History of prior cerebrovascular accident and Pregnant patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect on level of serum level of oxidative stress associated markers (superoxide dismutase, Glutathione peroxidase, Glutathione S-transferase, Malondialdehyde and t ROS) before and after surgery.Timepoint: 1.Before induction of anesthesia 2 Immediate postoperative period and 3 48 hrs after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in level of serum level of cytokines (IL-1β, IL-6, IL-17, IL-33 and TNF-α; IL-10 and TGF-beta) before and after surgery. 2. Change in level of immune cells (neutrophil subsets, T cells, monocytes) before and after surgery. 3. Change in level of serum level of epinephrine/norepinephrine before and after surgery.Timepoint: 1. Before induction of anesthesia 2. Immediate postoperative period and 3. 48 hrs after surgery | — |
Countries
India
Contacts
Public ContactDr Charu Mahajan
AIIMS, New Delhi
Outcome results
None listed