PREVENTION of LOW BLOOD PRESSURE AFTER SPINAL ANAESTHESIA IN CAESAREAN SECTIONS BY COMBINATION OF INTRAVENOUS ONDANSETRON PLUS INTRAVENOUS GLYCOPYRROLATE VERSUS INTRAVENOUS ONDANSETRON PLUS INTRAMUSCULAR GLYCOPYRROLATE.

TO ESTIMATE THE EFFICACY OF PRE-EMPTIVE COMBINATION OF INTRAVENOUS ONDANSETRON PLUS INTRAVENOUS GLYCOPYRROLATE VERSUS INTRAVENOUS ONDANSETRON PLUS INTRAMUSCULAR GLYCOPYRROLATE FOR REDUCTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN CAESAREAN SECTION

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/05/053038

Enrollment

Registered

2023-05-22

Start date

Unknown

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Intramuscular Glycopyrrolate: IM Glycopyrrolate 0.2mg 15 minutes before induction of anaesthesia and IV Ondansetron 4mg 15 minutes before induction of anaesthesia. Control Intervention1

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 & 2 pregnant females for elective and emergency LSCS surgery with written and informed consent

Exclusion criteria

Exclusion criteria: ASA grade 3 or more; Co morbid condition; contraindication to spinal anaesthesia; PIH; multiple gestation, haematological disorder; coagulopathy; placenta Previa; abruptio placenta ; Polyhydramnios; Morbid obesity, hemoglobin 100bpm at the time of PAC.

Design outcomes

Primary

Measure	Time frame
TO ESTMATE THE EFFICACY OF PRE-EMPTIVE COMBINATION OF INTRAVENOUS ONDANSETRON PLUS INTRAVENOUS GLYCOPYRROLATE VERSUS INTRAVENOUS ONDANSETRON AND INTRAMUSCULAR GLYCOPYRROLATE FOR REDUCTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN CAESAREAN SECTIONSTimepoint: 0 minute to 20 minutes	—

Secondary

Measure	Time frame
incidence and degree of hypotension, heart rate variations.Incidence of nausea and vomitingTimepoint: 0min, 2min, 4min, 6min, 8min, 10min, 12min, 14min, 16min, 18min, 20min.	—

Countries

India

Contacts

Public ContactDr Sandip Baheti

Dr. D. Y. Patil medical college, hospital and research centre

snbacademics12@gmail.com9822014401

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026