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Pre surgical decolonization and impact on surgical site infections , of patients undergoing cardiac surgery at AIIMS New Delhi

A randomized controlled trial to evaluate the efficacy of 2% Mupirocin vs 0.5% Neomycin vs placebo intranasal ointment on prevention of surgical site infections among adult patients undergoing cardiac surgery in AIIMS, New Delhi - RCT

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/05/053005
Enrollment
150
Registered
2023-05-22
Start date
Unknown
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I52- Other heart disorders in diseasesclassified elsewhere

Interventions

Intervention1: 0.5 % Neomycin intranasal ointment: Pea size amount of 0.5% Neomycin intranasal ointment will be applied twice at the time of admission and 2hours before the surgery on the anterior int

Sponsors

AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients in age groups greater than 18 years of age undergoing any kind of cardiac surgery. 2. Patients who are not taking antibiotics recently. 3. Patients who are not under treatment for any kind of infection.

Exclusion criteria

Exclusion criteria: 1. Patients having an allergy to 2% Mupirocin and 0.5% Neomycin. 2. Pregnant and lactating females undergoing cardiac surgeries. 3. Patients undergoing emergency cardiac surgeries. 4. Patients who have undergone re- exploration. 5. Patients who are on ECMO or IABP.

Design outcomes

Primary

MeasureTime frame
1.Reduction in the incidence and severity of surgical site infections after application of 2%mupirocin and 0.5% neomycin intranasal ointment to adult patients undergoing cardiac surgery 2.To compare the efficacy of 2% Mupirocin vs 0.5%Neomycin intranasal ointment in reducing the incidence of surgical site infections among adult patients undergoing cardiac surgery at AIIMS ,New DelhiTimepoint: 2nd ,8th 14th and 30th post operative day

Secondary

MeasureTime frame
1.To assess the incidence & severity of surgical site infections among adult patients undergoing cardiac surgery at AIIMS, New Delhi. 2.To find out the association between selected demographic variables & clinical profile data with surgical site infectionTimepoint: 2nd 8th 14th & 30th post operative day

Countries

India

Contacts

Public ContactDr Ujjwal Dahiya

AIIMS , NEW DELHI

pradeep.r.reddy85@gmail.com9968967087

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026