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The post operative analgesic effects of dexamethasone versus ondansetron as adjuvant to 0.25% bupivacaine bupivacaine via intraperitoneal infiltration in patients undergoing elective laparoscopic cholecystectomy

Comparative study of the analgesic efficacy of intraperitoneal instillation of dexamethasone versus ondansetron as adjuvants to bupivacaine 0.25% in patients undergoing elective laparoscopic cholecystectomy- A prospective randomised double blinded study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/05/052968
Enrollment
90
Registered
2023-05-22
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: INTRAPERITONEAL INSTILLATION OF DRUGS: INTRAPERITONEAL INSTILLATION OF 30 ML 0.25% BUPIVACAINE WITH 2 ML OR 8 MG DEXAMETHASONE OR 2ML OR 4MG ONDANSETRON AS ADJUVANTS ON THE GALL BLADDER

Sponsors

JSS HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I-II Surgery duration up to or less than 2 hours

Exclusion criteria

Exclusion criteria: Patient using Steroids or NSAIDS Patients with IHD/ Rhythm abnormalities. Patients with significant hepatic, renal or hematological disorders. Patients allergic to study drugs Patients and his/her legally accepted representatives not willing to provide their voluntary written informed consent for participation in the study. Surgery lasting for more than 2 hours If the surgery gets converted to open cholecystectomy Pregnant patients Any patient with postoperative drain Patients with BMI > 30

Design outcomes

Primary

MeasureTime frame
Significant reduction in post operative pain in patients who have received 8mg dexamethasone than 4mg ondansetron via intraperitoneal infiltrationTimepoint: IN A TIME PERIOD OF 24 HOURS POST SURGERY

Secondary

MeasureTime frame
Reduction in postoperative nausea and vomitingTimepoint: 24 hours

Countries

India

Contacts

Public ContactDR VINEETHA M

JSS MEDICAL COLLEGE AND HOSPITAL

vyshgiri@gmail.com9880110022

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026