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To study the effect of antiretroviral drugs on ageing and immunity in children living with HIV

EFFECT OF ANTI-RETROVIRAL THERAPY ON BIOLOGICAL AGING AND IMMUNOSENESCENCE IN CHILDREN LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/05/052950
Enrollment
81
Registered
2023-05-19
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B20- Human immunodeficiency virus [HIV]disease

Interventions

Control Intervention1: nil: nil

Sponsors

intramural research grant for pg thesis
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group 1: ART-naïve CLHIV, Group 2: CLHIV on ART (for >=1y duration on current ART regimen), Group 3: Age-matched healthy controls

Exclusion criteria

Exclusion criteria: Poor adherence to ART ( =1month duration, anti-tuberculous/ isoniazid preventive therapy (IPT), CLHIV on second line ART (virological failure) and those receiving immunomodulators or anti-oxidant supplements within the preceding 3 months

Design outcomes

Primary

MeasureTime frame
Telomere lengthTimepoint: 18 months—

Secondary

MeasureTime frame
T-cell receptor rearrangement excision circles (TREC) levels, CD4 counts,Correlation between TL, TREC levels and CD4 counts and the duration of ART, HIV viral load, and age at starting ART Timepoint: 18 months—

Countries

India

Contacts

Public ContactBadavath naresh

University College of Medical Sciences and GTB hospital

drpoojadewan@gmail.com9625900643

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026