Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: Active 40Hz Gamma Transcranial Alternating Current Stimulation: The study intervention consists of 10 sessions of active 40Hz gamma tACS delivered with a GTEN200 Neuromodulation System
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Schizophrenia using Diagnostic Criteria for Research (DCR) of International Classification of Disease-10th edition (ICD-10, World Health Organization, 1993). 2. Aged between 18- 60 years, right-handed individuals of either sex, giving informed consent. 3. An illness of duration more than 2 years & on stable dose of antipsychotics. 4. The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) negative symptoms score of more than 15. 5. Scale for Assessment of Negative Symptoms (SANS) score more than 20. 6. Calgary Depression Scale for Schizophrenia (CDSS) score less than 7. 7. Score less than or equal to 25 on screening with Hindi Montreal Cognitive Assessment Test (Hindi MoCA).
Exclusion criteria
Exclusion criteria: 1. Presence of comorbid neurological or other psychiatric disorder(s). 2. Patients with comorbid substance dependence in the last 6 months, except nicotine and caffeine. 3. Subjects who have received ECT in the past one month. 4. Patients with contraindications to MRI like pacemakers, metallic implants etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in negative symptoms in patients with schizophrenia as assessed by PANSS â?? Negative Symptoms Subscale and SANS. 2. Change in cognitive symptoms in patients with schizophrenia as assessed by MoCA, SCWT and TMT.Timepoint: 1. Change in negative symptoms in PANSS and SANS measured at baseline, 1 week and 4 weeks after initiation of treatment. 2. Change in MoCA, SCWT and TMT measured at baseline, 1 week and 4 weeks after initiation of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in gamma band spectral power and functional connectivity in patients with schizophrenia. 2. Change in CGI-I scores from baseline to post-treatment in patients with schizophrenia assessed by CGI-I Scale.Timepoint: 1. Change in gamma band spectral power and functional connectivity in patients with schizophrenia at baseline, after receiving first session and 1 week post-treatment. 2. Change in CGI-I score assessed at baseline, 1 week and 4 weeks post-treatment. | — |
Countries
India
Contacts
Public ContactUmesh S
Central Institute of Psychiatry
Outcome results
None listed