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A study to better understand the corneal infection from patient tear and swab samples

Proteomic and Metabolomic analysis of Microbial Keratitis Patients tears to identify biomarkers (molecular signatures) of corneal ulcer progression

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/05/052718
Enrollment
60
Registered
2023-05-16
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

None listed

Sponsors

United Kingdom Research and Innovation Future Leaders Fellowship
Lead Sponsor
Aravind Eye Hospital
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: a) Presence of corneal ulcer: defined as a corneal epithelial defect with underlying corneal infiltrate and signs of acute inflammation b) Appropriate written and informed consent

Exclusion criteria

Exclusion criteria: a) Less than 18 years b) No consent c) Suspected viral, acanthamoeba or mixed keratitis cases d) Microbial Keratitis in both eyes e) Use of steroids or anti-microbials for other conditions

Design outcomes

Primary

MeasureTime frame
a) To identify biomarkers by analyzing the ocular samples (tears) of microbial keratitis patients (proteomics and metabolomics) throughout treatment course. b) To define the contribution of the associated microorganisms to disease pathogenesis by studying the micro/mycobiome(conjunctival swabs) in disease and compared with healthy controls c) To relate biomarker findings to clinical outcomesTimepoint: 12 months—

Secondary

MeasureTime frame
NilTimepoint: Nil—

Countries

India

Contacts

Public ContactDr N Venkatesh Prajna

Aravind Eye Hospital

prajna@aravind.org914524356100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026