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Generation and evaluation of a composite matrix to reconstruct damaged or diseased knee joint defects

Designing and Evaluation of osteochondral matrix with zonal specific chondro- and osteo- differentiation potential to reconstruct damaged/diseased osteochondral defect.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/05/052686
Enrollment
20
Registered
2023-05-16
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

None listed

Sponsors

Manipal School of Life Sciences MAHE Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: People suffering from grade 4 osteoarthritis

Exclusion criteria

Exclusion criteria: Systematic arthritis or any comorbidities Previous chondral surjery Obesity or pregnancy Radiological osteoarthritis Severe alcoholism or drug abuse

Design outcomes

Primary

MeasureTime frame
To study the regenerative property offered by the composite scaffold towards the repair of osteochondral defectTimepoint: 4 weeks and 8 weeks—

Secondary

MeasureTime frame
To check the differentiation of the cells to chondrocytes and control differentiationTimepoint: 4 weeks and 8 weeks—

Countries

India

Contacts

Public ContactAnkitha S

Manipal School of Life Sciences

bhisham.singh@manipal.edu7978312019

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026