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A study to assess the effect of increased respiratory rate on pressure inside the brain by measuring the diameter of the sheath of the optic nerve of the eye (ONSD) using ultrasonography in patients undergoing surgery for brain tumours

Effect of hyperventilation on real-time Ultrasonography (USG) guided Optic Nerve Sheath Diameter (ONSD) changes in patients undergoing elective craniotomy for supratentorial tumours: A prospective observational study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/05/052682
Enrollment
114
Registered
2023-05-16
Start date
Unknown
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C718- Malignant neoplasm of overlappingsites of brain

Interventions

Control Intervention1: Normal ventilation: Ultrasonography guided Optic Nerve Sheath Diameter measurement baseline (End tidal Carbon Dioxide 34 mmHg) and after hyperventilation (End tidal Carbon Dioxi

Sponsors

P D Hinduja Hospital and Medical Research Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients suffering from supratentorial tumours ASA grade I to III

Exclusion criteria

Exclusion criteria: Ocular injuries Traumatic Brain injury Glaucoma Orbital tumours Open skull injuries Hyperthyroidism with ophthalmic signs present Patients who have been given diuretics or steroids within one hour prior to surgery

Design outcomes

Primary

MeasureTime frame
To determine whether intraoperative hyperventilation causes a significant change in Optic Nerve Sheath Diameter in neurosurgical patientsTimepoint: 1 minute after EtCO2 reaches 34 mm Hg... Time point 1 5 minutes after EtCO2 reaches 34 mm Hg... Time point 2 1 minute after EtCO2 reaches 24 mm Hg... Time point 3 5 minutes after EtCO2 reaches 24 mm Hg... Time point 4—

Secondary

MeasureTime frame
A. To determine whether any change in Optic Nerve Sheath Diameter guided changes in blood carbon dioxide levels by intraoperative hyperventilation can achieve an optimal Brain Relaxation score (BRS) B. To Correlate ONSD with EtCO2 and BRSTimepoint: 1. Arterial blood gas (ABG) analysis 1 minute after EtCO2 reaches 34 mm Hg 2. ABG 5 minutes after EtCO2 reaches 34 mm Hg 3. ABG 1 minute after EtCO2 reaches 24 mm Hg 4. ABG 5 minutes after EtCO2 reaches 24 mm Hg 5. EtCO2 and BRS after craniotomy done—

Countries

India

Contacts

Public ContactDr Saumyadipta S Pal

P D Hinduja Hospital and MRC

dr_shwetal.goraksha@hindujahospital.com9819570713

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026