Health Condition 1: G403- Generalized idiopathic epilepsy and epileptic syndromes
Conditions
Interventions
Intervention1: Probiotic: Multi strain probiotic preparation for 16 weeks
Control Intervention1: Placebo: Matching Placebo for 16 weeks
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Patients with DRE Age 18 years and above At least one seizure reported per month Currently receiving AEDs Provide Informed Consent
Exclusion criteria
Exclusion criteria: Time of onset of epilepsy treatment Non-epileptic seizures, Status epilepticus in the last 12 months, Changes in the AED type or dose in the last 30 days Active alcohol or substance overuse, Pregnancy and/or breastfeeding, Treatment with probiotics in the 30 days before Chronic gastrointestinal problems, hepatic or renal insufficiency, lactose intolerance, coeliac disease, immunodepression, long-term antibiotic use, a serious psychiatric condition, participating in any other epilepsy-related study Patients with poor compliance to AEDs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in seizure frequency Timepoint: 16 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota analysis QOL assessment Safety assessmentsTimepoint: 16 weeks | — |
Countries
India
Contacts
Public ContactAshish Kakkar
PGIMER
Outcome results
None listed