Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Sugammadex: Group A[ SUGAMMADEX] will receive Sugammadex 2mg/kg Intravenous on appearance of three twitches in NMT( neuromuscular monitoring)
it will be given ONCE for reversal of eff
Sponsors
Dr Prasanta Kumar Das
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective non-cardiac surgery 2. ASA grade I to III 3. AGE- 18- 70 Years
Exclusion criteria
Exclusion criteria: 1. Emergency surgery 2. Refusal to treatment 3. Allergy to study drug 4. Renal and hepatic failure 5. Pregnant and nursing mother 6. Diaphragmatic palsy 7. Poor image quality
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the incidence of PORC defined by diaphragmatic thickening fraction =0.36 , between two groups after administration of Neostigmine or Sugammadex assessed by diaphragm USG Timepoint: We will measure the thickening fraction of diaphragm by ultrasonography at three readings. The baseline will be taken before induction, just before extubation, at 30 minutes after extubation in postop area. All the outcomes will be assessed for 24 hours for taking the results into account. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare: 1)Time to achieve TOF ratio = 0.9 or four twitches since administration of last dose of muscle relaxant (whichever is later) 2)Time to achieve TOF ratio = 0.9 or four twitches after administration of reversal agent (whichever is later) 3)Postoperative pulmonary complications (PPC) within 24 hours [ PPC defined by SpO2 less than 90% or requiring oxygen therapy to maintain SpO2 more than 95% ] 3)Incidence of adverse effects Timepoint: within 24 hours | — |
Countries
India
Contacts
Public ContactAmlan Kusum Rout
AIIMS, Bhubaneswar
Outcome results
None listed