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Difference in effects of Milrinone given through vein or as gaseous mixture to the lung to reduce pressure in right side of the heart, in patients with narrowing of valve opening between left sided chambers undergoing Valve Replacement Surgery

Comparison of Nebulized Versus Intravenous Milrinone in reducing Pulmonary Arterial Pressure in Mitral stenosis patients with Pulmonary artery hypertension undergoing Valve Replacement Surgery: A single blinded, randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/05/052607
Enrollment
47
Registered
2023-05-12
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: I050- Rheumatic mitral stenosis

Interventions

Intervention1: Nebulised Milrinone: 50 microgram/kg dissolved in 5 ml normal saline through nebulisation after cross clamp release Control Intervention1: Intravenous Milrinone: Inj. milrinone 50 μg/k

Sponsors

IPGMER and SSKM Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Moderate to severe mitral stenosis 2. Preoperative mean pulmonary artery pressure more than 40 mm Hg

Exclusion criteria

Exclusion criteria: severe mitral regurgitation severe tricuspid regurgitation patient refusal known allergy to study drug hepatic or renal disease neurological disease

Design outcomes

Primary

MeasureTime frame
Mean pulmonary artery pressureTimepoint: After induction of anaesthesia 10 minutes after weaning of cardiopulmonary bypass 30 minutes after weaning of cardiopulmonary bypass 60 minutes after weaning of cardiopulmonary bypass—

Secondary

MeasureTime frame
Pulmonary vascular resistance indexTimepoint: After induction of anaesthesia 10 minutes after weaning of cardiopulmonary bypass 30 minutes after weaning of cardiopulmonary bypass 60 minutes after weaning of cardiopulmonary bypass;Systemic Vascular ResistanceTimepoint: After induction of anaesthesia 10 minutes after weaning of cardiopulmonary bypass 30 minutes after weaning of cardiopulmonary bypass 60 minutes after weaning of cardiopulmonary bypass;Arterial Blood PressureTimepoint: After induction of anaesthesia 10 minutes after weaning of cardiopulmonary bypass 30 minutes after weaning of cardiopulmonary bypass 60 minutes after weaning of cardiopulmonary bypass;Cardiac IndexTimepoint: After induction of anaesthesia 10 minutes after weaning of cardiopulmonary bypass 30 minutes after weaning of cardiopulmonary bypass 60 minutes after weaning of cardiopulmonary bypass;Central venous pressureTimepoint: After induction of anaesthesia 10 minutes after weaning of cardiopulmonary bypass 30 minutes after weaning of cardiopulmonary bypass 60 minutes after weaning of cardiopulmonary bypass;Heart Rate and RhythmTimepoint: After induction of anaesthesia 10 minutes after weaning of cardiopulmonary bypass 30 minutes after weaning of cardiopulmonary bypass 60 minutes after weaning of cardiopulmonary bypass—

Countries

India

Contacts

Public ContactChaitali Sen

Institute of Post graduate medical education and research

chaitali03@rediffmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026