Health Condition 1: O720- Third-stage hemorrhage
Conditions
Interventions
Intervention1: Carbetocin: A bolus of carbetocin 20mcg will be given intravenously over 1 minute, immediately after the delivery of the baby, followed by a placebo infusion till the caesarian section
Sponsors
CDSIMER
Eligibility
Inclusion criteria
Inclusion criteria: Full term pregnant women with singleton pregnancies coming for elective caesarian section
Exclusion criteria
Exclusion criteria: 1. Intrapartum caesarian sections. 2. Significant obstetric diseases like Gestational diabetes, Pre eclampsia, anemia. 3. Predisposing factors for post partum haemorrhage like uterine malformations, placental abnormalities, polyhydramnios, large baby, uterine fibroids, bleeding diatheses, previous history of post partum haemorrhage. 4.Allergy to the drugs used.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the effectiveness of low dose carbetocin in achieving uterine contractionTimepoint: Uterine contraction is estimated by the obstetrician at the following time intervals after the administration of the bolus - 1 min, 3 min, 5 min, 10 min, 20 min, 30 min and immediately after the closure of the abdomen | — |
Secondary
| Measure | Time frame |
|---|---|
| Need for additional doses of carbetocin or oxytocinTimepoint: will be noted whenever administered, till the end of surgery;need for second line uterotonic drugs like Methylergometrine and CarboprostTimepoint: Shall be noted whenever administered, till the end of surgery;To determine the incidence of tachycardia and hypotensionTimepoint: Heart rate and blood pressure will be measured at 1 minute, 3 minutes and 5 minutes after administration of the bolus followed by measurements every 5 minutes till the end of surgery | — |
Countries
India
Contacts
Public ContactDr Ajay S Shandilya
CDSIMER
Outcome results
None listed