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Effect of Quadripulse Transcranial Magnetic Stimulation in Alcohol Dependance

Effect of adjunctive Quadripulse Transcranial Magnetic Stimulation at left dorsolateral prefrontal cortex on resting and cue related functional connectivity, craving and withdrawal in Alcohol Dependance : a fMRI based randomized sham controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/05/052515
Enrollment
30
Registered
2023-05-11
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F102- Alcohol dependence

Interventions

Intervention1: Quadripulse Transcranial Magnetic Stimulation: Quadripulse Transcranial Magnetic Stimulation will be given at left dorsolateral prefrontal cortex for a total of 10 sessions with 2 sessi

Sponsors

Central Institute of Psychiatry
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with F10.24 Mental and behavioural disorders due to use of alcohol, dependence syndrome, currently using the substance [active dependence] 2. Last intake of alcohol at least 6 hours before admission, self-reported and corroborated by informants 3. Male 4. Age between 18 and 50 years 5. Ready to give informed consent 6. Right-handed 7. Drug naïve, Electroconvulsive Therapy naïve, and drug free of any psychotropic medications for at least 4 weeks.

Exclusion criteria

Exclusion criteria: 1. Age 50 years 2. Not willing to give informed consent 3. Any other co-morbid substance abuse except nicotine and caffeine 4. Participants having any co-morbid psychiatric disorders 5. Patients having metallic implant 6. Patients having known contraindication to undergoing Quadripulse Stimulation or fMRI 7. Patient on any anti craving medication during study period and preceding 4 weeks.

Design outcomes

Primary

MeasureTime frame
1. Change in score of alcohol craving questionnaire (ACQ-NOW) from baseline to end of last QPS sessions and after 28 days from last QPS session 2. Change in score of obsessive-compulsive drinking scale (OCDUS) from baseline to end of last QPS sessions and after 28 days from last QPS session 3. Change in CIWA-Ar scores baseline to end of last QPS session 4. Number of days to reach CIWA-Ar score 10Timepoint: Baseline (day2) ACQ-NOW, OCDUS, HAM-A, HAM-D (day8) CGI-I, CIWA-Ar (day3, 4, 5, 6, 7, 8) all of the above (day 35)—

Secondary

MeasureTime frame
1. Change in resting state functional connectivity of executive control network and salience ventral attention network from baseline to end of last QPS sessions. 2. Change in cue related functional connectivity of executive control network and salience ventral attention network baseline to end of last QPS sessions. 3. Dosage of benzodiazepines required during detoxification (baseline to CIWA-Ar 10) 4. Changes in CGI-I scores from baselineTimepoint: day0 day7—

Countries

India

Contacts

Public ContactDr Sourav Khanra

Central Institute of Psychiatry

souravpsy@gmail.com7903302259

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026