Health Condition 1: A519- Early syphilis, unspecified
Conditions
Interventions
Intervention1: tab.doxycycline: 100mg bd for 14 days
Control Intervention1: inj.benzathine penicillin: 2.4 million IU im stat dose
Sponsors
SCHOOL OF TROPICAL MEDICINE
Eligibility
Inclusion criteria
Inclusion criteria: 1)Age more than 18 years and of all genders with laboratory confirmed new cases of early syphilis with a plasma rapid plasma regain (RPR) >_ 1:8 and serum TPHA positivity. 2)HIV infected individuals with laboratory confirmed new cases of early syphilis with a plasma rapid plasma regain (RPR) >_ 1:8 and serum TPHA positivity. 3)Able to travel to clinic once a day or be available for phone calls or receive a text message.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1) Pregnant females 2) Recent (within the past 7days) or concomitant antimicrobial therapy with activity against syphilis, namely azithromycin, doxycycline, ceftriaxone or beta lactam antibiotics (e.g., amoxicillin) 3)elevated RPR test without any clinical corelation. (Biologic false positives) 4) A medical condition or other factors that might affect their ability to follow the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serological efficacy of penicillin versus doxycyclineTimepoint: 3 months 6 months 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| to monitor adverse effects of penicillin versus doxycyclineTimepoint: immediate after administration one hour after administration 3 months 6 months 12 months | — |
Countries
India
Contacts
Public ContactVASIREDDY TEJA
SCHOOL OF TROPICAL MEDICINE
Outcome results
None listed