Clinical trial to study effect of levobupivacaine versus adding ketamine to levobupivacaine to relieve post operative pain in one sided total knee replacement patients by using ultrasound guided adductor canal block

A comparative study between levobupivacaine versus levobupivacaine plus ketamine as adjuvant for post operative analgesia in ultrasound guided adductor canal block in patients undergoing unilateral total knee replacement surgery: A prospective randomized study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/05/052456

Enrollment

Registered

2023-05-10

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Injection Levobupivacaine: Injection Levobupivacaine 0.25%

total volume of 20ml given in ultrasound guided adductor canal block in unilateral total knee replacement patients after surgery Control Intervention1: Injection Levobupivacaine plus injection ketamin

total volume of 20ml given in ultrasound guided adductor canal block in unilateral total knee replacement patients after surgery

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA 1 & 2 2. U/L TKR patients under spinal anesthesia 3. Patient age between 18 to 75 years

Exclusion criteria

Exclusion criteria: 1. Patient with known allergic reaction history to lignocaine, levobupivacaine & ketamine 2. Body mass index (BMI) >35kg/m2 3. Pre-existing peripheral neuropathy or neurological deficit in lower extremities 4. Coagulopathy 5. Infection at site of block 6. Refusal for consent 7. Psychiatric disorder 8. Prior knee surgery on same limb or lower limb deformity of the same limb 9. Pregnancy and lactating mothers 10. Use of any regional block other than ACB as postoperative analgesia

Design outcomes

Primary

Measure	Time frame
To compare duration of post operative analgesia using levobupivacaine and levobupivacaine plus ketamine as adjuvant in adductor canal block in unilateral total knee replacement patientsTimepoint: Note time when numeric rating scale is more than or equal to 4 time point: 24 hours	—

Secondary

Measure	Time frame
To assess amount of rescue analgesia (Tramadol as rescue analgesia) required after using levobupivacaine and levobupivacaine plus ketamine as adjuvant in adductor canal block in unilateral total knee replacement patientsTimepoint: Time of first dose & total tramadol consumption noted in 24 hours after surgery	—

Countries

India

Contacts

Public ContactDr Navneh Samagh

All India Institute of Medical Sciences, Bathinda

dksbhu@gmail.com07380005544

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026